Sim1^Rgsc646
Chemically induced Allele Detail

Summary

• Symbol: Sim1^Rgsc646
• Name: single-minded family bHLH transcription factor 1; RIKEN Genomic Sciences Center (GSC), 646
• MGI ID: MGI:3812149
• Synonyms: M100646
• Gene: Sim1 Location: Chr10:50770850-50865248 bp, + strand Genetic Position: Chr10, 24.87 cM, cytoband B3-B4
• Alliance: Sim1^Rgsc646 page

Mutation origin

• Strain of Origin: C57BL/6JJcl
• Project Collection: RIKEN GSC ENU Project

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: This mutation, discovered in an ENU mutagenesis screen, has been identified as a GT to GA substitution in the splicing donor site of exon 9. It may result in abnormal splicing and/or nonsense mediated decay. (J:133634)
• Inheritance: Dominant

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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ht1	Sim1^Rgsc646/Sim1^+	involves: C57BL/6JJcl * DBA/2JJcl

Phenotypes:

Affected Systems	ht1
show or hide all annotated terms
growth/size/body	√
obese	√
hematopoietic system	√
increased glycosylated hemoglobin level	√
homeostasis/metabolism	√
increased glycosylated hemoglobin level	√
hyperglycemia	√
increased circulating insulin level	√
increased urine glucose level	√
insulin resistance	√
renal/urinary system	√
increased urine glucose level	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sim1 Mutation: 52 strains or lines available

References

• Original: J:133634 RIKEN BioResource Center/RIKEN Genomic Sciences Center, A Large Scale Mutagenesis Program in RIKEN GSC. PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/). 2008
• All: 2 reference(s)