Sim1Rgsc646
Chemically induced Allele Detail
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Symbol: |
Sim1Rgsc646 |
Name: |
single-minded family bHLH transcription factor 1; RIKEN Genomic Sciences Center (GSC), 646 |
MGI ID: |
MGI:3812149 |
Synonyms: |
M100646 |
Gene: |
Sim1 Location: Chr10:50770850-50865248 bp, + strand Genetic Position: Chr10, 24.87 cM, cytoband B3-B4
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Alliance: |
Sim1Rgsc646 page
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Strain of Origin: |
C57BL/6JJcl
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Project Collection: |
RIKEN GSC ENU Project
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Allele Type: |
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Chemically induced (ENU) |
Mutation: |
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Nucleotide substitutions
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Mutation details: This mutation, discovered in an ENU mutagenesis screen, has been identified as a GT to GA substitution in the splicing donor site of exon 9. It may result in abnormal splicing and/or nonsense mediated decay.
(J:133634)
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Inheritance: |
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Dominant |
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6JJcl * DBA/2JJcl | |
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Phenotypes: |
Affected Systems |
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growth/size/body
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√
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obese
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√
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hematopoietic system
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√
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increased glycosylated hemoglobin level
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√
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homeostasis/metabolism
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√
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increased glycosylated hemoglobin level
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√
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hyperglycemia
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√
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increased circulating insulin level
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√
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increased urine glucose level
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√
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insulin resistance
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√
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renal/urinary system
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√
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increased urine glucose level
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:133634 RIKEN BioResource Center/RIKEN Genomic Sciences Center, A Large Scale Mutagenesis Program in RIKEN GSC. PhenoSITE, World Wide Web (URL: http://www.brc.riken.jp/lab/gsc/mouse/). 2008; |
All: |
2 reference(s) |
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