Tg(TcraB12,TcrbB12)1Rest
Transgene Detail

Summary

• Symbol: Tg(TcraB12,TcrbB12)1Rest
• Name: transgene insertion 1, Nicholas Restifo
• MGI ID: MGI:3812191
• Synonyms: BgII^TG
• Transgene: Tg(TcraB12,TcrbB12)1Rest Location: unknown
• Alliance: Tg(TcraB12,TcrbB12)1Rest page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraB12,TcrbB12)1Rest expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: RNA was isolated from an I-A^b restricted, Beta-gal specific CD4⁺ T cell clone. The variable domains for both the Tcra and Tcrb genes were cloned into TCR cassette vectors and co-injected into fertilized embryos. Transgenic mice produce T cells that recognize peptides from the product of the LacZ gene. (J:140121, J:140160)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:140121 Ahn S, et al., TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation. PLoS Biol. 2008 Aug 5;6(8):e191
• All: 3 reference(s)