Ctla4^tm1Saka
Targeted Allele Detail

Summary

• Symbol: Ctla4^tm1Saka
• Name: cytotoxic T-lymphocyte-associated protein 4; targeted mutation 1, Shimon Sakaguchi
• MGI ID: MGI:3812204
• Synonyms: CTLA-4^fl, Ctla-4^flox
• Gene: Ctla4 Location: Chr1:60948184-60954991 bp, + strand Genetic Position: Chr1, 30.58 cM, cytoband C
• Alliance: Ctla4^tm1Saka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140085
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a frt-flanked neomycin cassette followed by another loxP site was placed downstream of exon 3. Endogenous gene expression was unaffected in homozygous mice as determined by flow cytometry on freshly isolated lymphocytes. (J:140085)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctla4 Mutation: 54 strains or lines available

References

• Original: J:140085 Wing K, et al., CTLA-4 control over Foxp3+ regulatory T cell function. Science. 2008 Oct 10;322(5899):271-5
• All: 11 reference(s)