Dsc3^tm2Pko
Targeted Allele Detail

Summary

• Symbol: Dsc3^tm2Pko
• Name: desmocollin 3; targeted mutation 2, Peter J Koch
• MGI ID: MGI:3812225
• Synonyms: Dsc3^fl
• Gene: Dsc3 Location: Chr18:20093987-20135408 bp, - strand Genetic Position: Chr18, 11.11 cM
• Alliance: Dsc3^tm2Pko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140129
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 1. Transient flp expression in ES cells was used to remove the neo cassette leaving exon 1 floxed. (J:140129)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dsc3 Mutation: 49 strains or lines available

References

• Original: J:140129 Chen J, et al., Loss of desmocollin 3 in mice leads to epidermal blistering. J Cell Sci. 2008 Sep 1;121(Pt 17):2844-9
• All: 2 reference(s)