Cxadr^tm1Mgot
Targeted Allele Detail

Summary

• Symbol: Cxadr^tm1Mgot
• Name: coxsackie virus and adenovirus receptor; targeted mutation 1, Michael Gotthardt
• MGI ID: MGI:3812340
• Synonyms: CAR^recf
• Gene: Cxadr Location: Chr16:78098377-78156662 bp, + strand Genetic Position: Chr16, 45.28 cM, cytoband C
• Alliance: Cxadr^tm1Mgot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1, which contains the translation start, was replaced with a floxed exon 1 and an upstream FRT-flanked neomycin resistance cassette. The neomycin resistance cassette was removed by germline expression of the FLP recombinase after targeting. Upon expression of cre recombinase, exon 1 is excised creating a null allele. (J:140109)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxadr Mutation: 15 strains or lines available

References

• Original: J:140109 Lisewski U, et al., The tight junction protein CAR regulates cardiac conduction and cell-cell communication. J Exp Med. 2008 Sep 29;205(10):2369-79
• All: 5 reference(s)