Gabra2^tm1Dns
Targeted Allele Detail

Summary

• Symbol: Gabra2^tm1Dns
• Name: gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 1, D N Stephens
• MGI ID: MGI:3812421
• Gene: Gabra2 Location: Chr5:71115735-71253192 bp, - strand Genetic Position: Chr5, 37.59 cM
• Alliance: Gabra2^tm1Dns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140077
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a floxed neo cassette. Germ line, cre mediated recombination was used to remove the neo cassette. (J:140077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra2 Mutation: 36 strains or lines available

References

• Original: J:140077 Dixon CI, et al., Targeted deletion of the GABRA2 gene encoding alpha2-subunits of GABA(A) receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates. Pharmacol Biochem Behav. 2008 Jul;90(1):1-8
• All: 3 reference(s)