Reg2^tm1Lchr
Targeted Allele Detail

Summary

• Symbol: Reg2^tm1Lchr
• Name: regenerating islet-derived 2; targeted mutation 1, Laurence Christa
• MGI ID: MGI:3812476
• Synonyms: Reg3b^-, RegIIIbeta^-
• Gene: Reg2 Location: Chr6:78382138-78385082 bp, + strand Genetic Position: Chr6, 34.77 cM, cytoband C
• Alliance: Reg2^tm1Lchr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140235
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic region containing part of exon 2 through part of exon 5 was replaced with and IRES-tau, lacZ and floxed neo cassette. The absence of protein expression was confirmed by immunohistochemistry on nervous tissue and the absence of transcript expression as confirmed by RT-PCR analysis on brain and regenerating liver extracts. (J:140235)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Reg2 Mutation: 12 strains or lines available

References

• Original: J:140235 Lieu HT, et al., Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice. Hepatology. 2006 Dec;44(6):1452-64
• All: 7 reference(s)