Elfn1^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Elfn1^{tm1(KOMP)Vlcg}
• Name: leucine rich repeat and fibronectin type III, extracellular 1; targeted mutation 1, Velocigene
• MGI ID: MGI:3812600
• Synonyms: Elfn1^tm1Vlcg
• Gene: Elfn1 Location: Chr5:139893698-139960477 bp, + strand Genetic Position: Chr5, 78.81 cM
• Alliance: Elfn1^{tm1(KOMP)Vlcg} page
• IMPC: Elfn1 gene page

Mutation origin

• Mutant Cell Lines: 10112A-C9, 10112C-B9, 10112C-F5, 10112D-B12
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 2504bp between positions 139956981-139959484 of Chromosome 5 (Build GRCm39). The full coding sequence of exon 2 was replaced with beta-galactosidase and loxP-flanked neomycin casette. PCR analysis confirmed the loss of exon 2 in homozygous mutants. (J:136110, J:209758)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Elfn1 Mutation: 32 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 11 reference(s)