Gnb3^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Gnb3^{tm1(KOMP)Vlcg}
• Name: guanine nucleotide binding protein (G protein), beta 3; targeted mutation 1, Velocigene
• MGI ID: MGI:3812642
• Synonyms: Gnb3^tm1Vlcg
• Gene: Gnb3 Location: Chr6:124811203-124817238 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Gnb3^{tm1(KOMP)Vlcg} page
• IMPC: Gnb3 gene page

Mutation origin

• Mutant Cell Lines: 10605A-A7, 10605A-A8, 10605A-B1, 10605A-B2, 10605A-E6, 10605A-G11
• Germline Transmission: Earliest citation of germline transmission: J:187720
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 5082bp between positions 124811599-124816680 of Chromosome 6 (Build GRCm39). Western blot analysis confirmed the absence of protein expression in retina. (J:136110, J:187720)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Gnb3 Mutation: 23 strains or lines available

Notes

No mutant cell line is specified in J:187720.

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 5 reference(s)