Lmod2^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Lmod2^{tm1(KOMP)Vlcg}
• Name: leiomodin 2 (cardiac); targeted mutation 1, Velocigene
• MGI ID: MGI:3812792
• Synonyms: Lmod2^tm1Vlcg
• Gene: Lmod2 Location: Chr6:24597770-24605413 bp, + strand Genetic Position: Chr6, 11.28 cM, cytoband A3
• Alliance: Lmod2^{tm1(KOMP)Vlcg} page
• IMPC: Lmod2 gene page

HSPB7 represses formation of abnormal actin bundles independent of Lmod2

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Lines: 10985A-B9, 10985A-C6, 10985A-F1, 10985B-B4, 10985B-C3, 10985B-C11, 10985B-G6
• Germline Transmission: Earliest citation of germline transmission: J:227272
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 7346bp between positions 24597866-24605211 of Chromosome 6 (Build GRCm39). The entire gene starting at the translational start site and ending at the translational stop site, was replaced with the lacZ reporter cassette. Western blot confirmed complete loss of protein in the left ventricle. (J:136110, J:227272)

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Lmod2 Mutation: 27 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 5 reference(s)