Dmrt3^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Dmrt3^{tm1(KOMP)Vlcg}
• Name: doublesex and mab-3 related transcription factor 3; targeted mutation 1, Velocigene
• MGI ID: MGI:3812826
• Synonyms: Dmrt3^tm1Vlcg
• Gene: Dmrt3 Location: Chr19:25587665-25601285 bp, + strand Genetic Position: Chr19, 20.5 cM
• Alliance: Dmrt3^{tm1(KOMP)Vlcg} page
• IMPC: Dmrt3 gene page

Mutation origin

• Mutant Cell Lines: 11087A-H3, 11087C-B1, 11087C-B11, 11087C-C11
• Germline Transmission: Earliest citation of germline transmission: J:203109
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 12422bp between positions 25588166-25600587 of Chromosome 19 (Build GRCm39). (J:136110)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Dmrt3 Mutation: 12 strains or lines available

Notes

Cell line 11087C-C11 was successfully used to make chimeric mice. Germline transmission was accomplished. J:203109

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 3 reference(s)