Ccdc87^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Ccdc87^{tm1(KOMP)Vlcg}
• Name: coiled-coil domain containing 87; targeted mutation 1, Velocigene
• MGI ID: MGI:3812849
• Synonyms: Ccdc87^-, Ccdc87^tm1Vlcg
• Gene: Ccdc87 Location: Chr19:4889394-4892556 bp, + strand Genetic Position: Chr19, 4.11 cM
• Alliance: Ccdc87^{tm1(KOMP)Vlcg} page
• IMPC: Ccdc87 gene page

Mutation origin

• Mutant Cell Lines: 11192A-F3, 11192A-G3, 11192A-H2
• Germline Transmission: Earliest citation of germline transmission: J:265624
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 2623bp between positions 4889494-4892116 of Chromosome 19 (Build GRCm39). The single exon was replaced by a LacZ reporter cassette followed by a neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the testis and cauda epididymal sperm from homozygous mutant mice. (J:136110, J:265624)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Ccdc87 Mutation: 29 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 2 reference(s)