Ep300^Plt6
Chemically induced Allele Detail

Summary

• Symbol: Ep300^Plt6
• Name: E1A binding protein p300; Plt6
• MGI ID: MGI:3813243
• Synonyms: p300^Plt6, p300^Y630N
• Gene: Ep300 Location: Chr15:81470329-81536273 bp, + strand Genetic Position: Chr15, 38.16 cM
• Alliance: Ep300^Plt6 page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A single T to A mutation occurred resulting in a substitution of tyrosine for asparagine at residue 630 within the KIX domain of the protein product. Computer modeling identified several putative hydrophobic interactions that could be disrupted by this Y630N mutation and cause structural distortion. Recombinant protein containing this point mutation have 7-fold reduction in binding to c-Myb protein. (J:140200)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ep300 Mutation: 98 strains or lines available

References

• Original: J:140200 Kauppi M, et al., Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice. Blood. 2008 Oct 15;112(8):3148-53
• All: 3 reference(s)