Tg(Ppp1r1b-HTT*)1Meeh
Transgene Detail

Summary

• Symbol: Tg(Ppp1r1b-HTT*)1Meeh
• Name: transgene insertion 1, Michelle E Erlich
• MGI ID: MGI:3813481
• Synonyms: D9-N171-98Q, DE5
• Transgene: Tg(Ppp1r1b-HTT*)1Meeh Location: unknown
• Alliance: Tg(Ppp1r1b-HTT*)1Meeh page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ppp1r1b-HTT*)1Meeh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTT (3064)

  Htt	(MGI:96067)

• Mutation details: A 9 kb genomic fragment containing mouse Ppp1r1b was used to drive expression of an IRES fused cDNA for human HTT that encodes for the first 171 amino acids with an expanded CAG repeat of 98 nucleotides in length in the medium spiny neurons of the striatum. No line information is available. (J:139807)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:139807 Brown TB, et al., Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse. Hum Mol Genet. 2008 Oct 15;17(20):3095-104
• All: 2 reference(s)