Tg(H2-K-Fosl2,-EGFP)13Wag
Transgene Detail

Summary

• Symbol: Tg(H2-K-Fosl2,-EGFP)13Wag
• Name: transgene insertion 13, Erwin F Wagner
• MGI ID: MGI:3813493
• Synonyms: fra-2^tg, Tg(H2-K-Fosl2,EGFP)13Wag
• Transgene: Tg(H2-K-Fosl2,-EGFP)13Wag Location: unknown
• Alliance: Tg(H2-K-Fosl2,-EGFP)13Wag page

Transgene origin

• Strain of Origin: C57BL/6 x CBA

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K-Fosl2,-EGFP)13Wag expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fosl2 (MGI:102858)

• Mutation details: The ubiquitous H2-K^b promoter was used to drive expression of the cDNA encoding Fosl2 followed by an IRES-EGFP. Three founders were identified (12, 13 and 15). Lines 12 and 13 display the same phenotype while founder 15 failed to express the transgene. Line 13 was used in subsequent analysis. (J:139032)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:139032 Eferl R, et al., Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10525-30
• All: 12 reference(s)