Sync^tm1.1Ked
Targeted Allele Detail

Summary

• Symbol: Sync^tm1.1Ked
• Name: syncoilin; targeted mutation 1.1, Kay E Davies
• MGI ID: MGI:3813569
• Gene: Sync Location: Chr4:129181410-129202352 bp, + strand Genetic Position: Chr4, 63.26 cM
• Alliance: Sync^tm1.1Ked page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138552
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an frt flanked neomycin selection cassette were inserted in intron 1 and a second loxP site was placed in intron 2. Chimeric mice were bred to a proprietary CMV-cre mouse line on a C57BL/6 background developed by GenOway. This resulted in the excision of both the neomycin selection cassette and exon 2. No protein was detectable immunologically in tissues. (J:138552)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sync Mutation: 21 strains or lines available

Notes

This targeted mutation was created in "E129/sv" ES cells.

References

• Original: J:138552 McCullagh KJ, et al., Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse. Mamm Genome. 2008 May;19(5):339-51
• All: 2 reference(s)