Tg(CAG-cat,-TBX3)1Vmc
Transgene Detail

Summary

• Symbol: Tg(CAG-cat,-TBX3)1Vmc
• Name: transgene insertion 1, Vincent M Christoffels
• MGI ID: MGI:3813723
• Synonyms: CAG-CAT-TBX3, CT, CT3, CTBX3^-
• Transgene: Tg(CAG-cat,-TBX3)1Vmc Location: unknown
• Alliance: Tg(CAG-cat,-TBX3)1Vmc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-cat,-TBX3)1Vmc expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TBX3 (6926)

  Tbx3	(MGI:98495)

• Mutation details: This transgene consists of the CAG promoter (the cytomegalovirus immediate early (CMV-EI) enhancer followed by a 1.3-kb DNA segment including the promoter, first exon and first intron of the chicken beta-actin gene, with the 3' splice junction sequence replaced by that of the rabbit hemoglobin beta gene), a floxed chloramphenicol acetyltransferase (cat) gene with the SV40 small t intron and polyadenylation signal, and a full length human TBX3 cDNA with an in frame fusion to a hemagglutinin tag. Cre mediated recombination removes the cat gene allowing expression of TBX3. (J:121230)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:121230 Hoogaars WM, et al., Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007 May 1;21(9):1098-112
• All: 5 reference(s)