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Tg(CAG-cat,-TBX3)1Vmc
Transgene Detail
Summary
Symbol: Tg(CAG-cat,-TBX3)1Vmc
Name: transgene insertion 1, Vincent M Christoffels
MGI ID: MGI:3813723
Synonyms: CAG-CAT-TBX3, CT, CT3, CTBX3-
Transgene: Tg(CAG-cat,-TBX3)1Vmc  Location: unknown  
Alliance: Tg(CAG-cat,-TBX3)1Vmc page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(CAG-cat,-TBX3)1Vmc expresses 1 gene
 
Mutation detailsThis transgene consists of the CAG promoter (the cytomegalovirus immediate early (CMV-EI) enhancer followed by a 1.3-kb DNA segment including the promoter, first exon and first intron of the chicken beta-actin gene, with the 3' splice junction sequence replaced by that of the rabbit hemoglobin beta gene), a floxed chloramphenicol acetyltransferase (cat) gene with the SV40 small t intron and polyadenylation signal, and a full length human TBX3 cDNA with an in frame fusion to a hemagglutinin tag. Cre mediated recombination removes the cat gene allowing expression of TBX3. (J:121230)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:121230 Hoogaars WM, et al., Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev. 2007 May 1;21(9):1098-112
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory