Tet2^{Gt(Ayu17-449)Imeg}
Gene trapped Allele Detail

Summary

• Symbol: Tet2^{Gt(Ayu17-449)Imeg}
• Name: tet methylcytosine dioxygenase 2; gene trap Ayu17-449, Institute of Molecular Embryology and Genetics
• MGI ID: MGI:3813933
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^{Gt(Ayu17-449)Imeg} page

Mutation origin

• Mutant Cell Line: Ayu17-449
• Germline Transmission: Earliest citation of germline transmission: J:140275
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Gene trapped (RMCE-ready)
• Mutations: Insertion of gene trap vector, Intragenic deletion
• Mutation details: The gene trap vector pUC17, which contains an En splice acceptor, lox71 site, lacZ gene, neo cassette, loxP site and lox2272 site, was inserted into intron 2 upstream of the translation initiation codon in exon 3. Insertion of the gene trap vector using cre mediated cassette exchange results in the deletion of 10 bp. The absence of transcript expression was confirmed by RT-PCR. (J:140275)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tet2^{Gt(Ayu17-449)Imeg}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 779 strains or lines available

References

• Original: J:140275 Tang H, et al., Characterization of Ayu17-449 gene expression and resultant kidney pathology in a knockout mouse model. Transgenic Res. 2008 Aug;17(4):599-608
• All: 13 reference(s)