Rap1a^tm1Laaq
Targeted Allele Detail

Summary

• Symbol: Rap1a^tm1Laaq
• Name: RAS-related protein 1a; targeted mutation 1, Lawrence A Quilliam
• MGI ID: MGI:3813936
• Gene: Rap1a Location: Chr3:105634583-105708652 bp, - strand Genetic Position: Chr3, 46.45 cM
• Alliance: Rap1a^tm1Laaq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140471
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot on purified neutrophils and various organ extracts. (J:140471)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rap1a Mutation: 25 strains or lines available

References

• Original: J:140471 Li Y, et al., Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol. 2007 Dec 15;179(12):8322-31
• All: 8 reference(s)