Tg(GFAP-cre/Esr1*,-lacZ)BSbk
Transgene Detail

Summary

• Symbol: Tg(GFAP-cre/Esr1*,-lacZ)BSbk
• Name: transgene insertion B, Suzanne J Baker
• MGI ID: MGI:3813947
• Synonyms: GFAP-CreER^TM, GFAP-CreER^TMB, Tg(GFAP-cre/Esr1)BSbk
• Transgene: Tg(GFAP-cre/Esr1*,-lacZ)BSbk Location: unknown Genetic Position: Chr15, Syntenic
• Alliance: Tg(GFAP-cre/Esr1*,-lacZ)BSbk page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(GFAP-cre/Esr1*,-lacZ)BSbk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  GFAP (2670)

  Gfap	(MGI:95697)

• Mutation details: This transgene consists of a 2.2 kb fragment of the human GFAP promoter, a cDNA encoding a fusion of cre and the ligand binding domain of the human estrogen receptor modified to bind 4-hydroxytamoxifen, but not endogenous estrogen, an IRES, a cDNA encoding beta-galactosidase, and SV40 intronic sequence and polyadenylation signal. Transgene expression, assessed by beta-gal activity, is seen in Bergmann glia, neuronal precursors in the dentate gyrus, and cells in the subventricular zone surrounding the lateral ventricle. When crossed to reporter mice occasional tamoxifen-independent Cre mediated recombination is seen primarily in Bergmann glial cells. (J:140270)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	GFAP (human) Summary of all recombinase alleles driven by GFAP. Comparative matrix view of recombinase activities Alliance human GFAP gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:140270 Chow LM, et al., Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res. 2008 Oct;17(5):919-28
• All: 7 reference(s)