Ednrb^tm1Nrd
Targeted Allele Detail

Summary

• Symbol: Ednrb^tm1Nrd
• Name: endothelin receptor type B; targeted mutation 1, Noah Druckenbrod
• MGI ID: MGI:3813973
• Synonyms: Ednrb^flex3
• Gene: Ednrb Location: Chr14:104052055-104081764 bp, - strand Genetic Position: Chr14, 53.05 cM
• Alliance: Ednrb^tm1Nrd page

Evidence of inflammation in both the proximal and mid-colon of the Ednrb^tm1Nrd/Ednrb^tm1Nrd Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/0 animals

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140320
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was placed upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. (J:140320)

Disease models

Expression

In Mice Carrying this Mutation:	24 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ednrb Mutation: 104 strains or lines available

References

• Original: J:140320 Druckenbrod NR, et al., Targeting of endothelin receptor-B to the neural crest. Genesis. 2008 Aug;46(8):396-400
• All: 13 reference(s)