Dcaf1^tm1.1Yxi
Targeted Allele Detail

Summary

• Symbol: Dcaf1^tm1.1Yxi
• Name: DDB1 and CUL4 associated factor 1; targeted mutation 1.1, Yue Xiong
• MGI ID: MGI:3814062
• Synonyms: VprBP^flox
• Gene: Dcaf1 Location: Chr9:106699073-106758191 bp, + strand Genetic Position: Chr9, 57.98 cM
• Alliance: Dcaf1^tm1.1Yxi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140246
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted before exon7 and after exon 8 and an Frt flanked neo cassette was inserted upstream of the 5' loxP site via homologous recombination. Transient Flp expression resulted in deletion of the neo cassette. (J:140246)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dcaf1 Mutation: 70 strains or lines available

References

• Original: J:140246 McCall CM, et al., Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. Mol Cell Biol. 2008 Sep;28(18):5621-33
• All: 9 reference(s)