Fads2^tm1Wst
Targeted Allele Detail

Summary

• Symbol: Fads2^tm1Wst
• Name: fatty acid desaturase 2; targeted mutation 1, Wilhelm Stoffel
• MGI ID: MGI:3814170
• Gene: Fads2 Location: Chr19:10040129-10078867 bp, - strand Genetic Position: Chr19, 6.36 cM, cytoband B
• Alliance: Fads2^tm1Wst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140341
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The start codon of exon 1 was deleted and a pgk-neo cassette was inserted in exon 1 via homologous recombination. RT-PCR confirmed the absence of transcripts in all tissues examined. (J:140341)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fads2 Mutation: 21 strains or lines available

References

• Original: J:140341 Stoffel W, et al., Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids. EMBO J. 2008 Sep 3;27(17):2281-92
• All: 5 reference(s)