Gt(ROSA)26Sor^tm1(Tva)Dsa
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(Tva)Dsa
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Dieter Saur
• MGI ID: MGI:3814188
• Synonyms: LSL-R26^lacZ, LSL-R26^Tva-lacZ, R26^LSL-TVA, R26^LSL-TVAilacZ
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(Tva)Dsa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140423
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The tumor virus A (Tva) sequence disrupted with a lox-stop-lox cassette after the initiation codon, an IRES element and lacZ were inserted into intron 1 via homologous recombination. Cre mediated recombination results in expression of TVA and lacZ. Expression of TVA makes cells vulnerable to infection by RCAS (replication-competent sarcoma-leukosis virus long terminal repeat with splice acceptor) vector with Bryan-RSV polymerase and subgroup A envelope viruses (RCASBP(A)). (J:140423)

Tumor Data

List all tumor models in MMHCdb carrying Gt(ROSA)26Sor^tm1(Tva)Dsa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:140423 Seidler B, et al., A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10137-42
• All: 26 reference(s)