Ildr2^Dbsm1-DBA/2J
QTL Variant Detail

Summary

• QTL variant: Ildr2^Dbsm1-DBA/2J
• Name: immunoglobulin-like domain containing receptor 2; DBA/2J
• MGI ID: MGI:3814224
• QTL: Ildr2 Location: Chr1:166081708-166144392 bp, + strand Genetic Position: Chr1, 73.61 cM

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers decreased beta-cell mass, impaired glucose tolerance, increased fasting blood glucose levels and decreased blood insulin in obese Lepob males on a CHOW diet compared to C57BL/6J. This allele confers increased blood glucose levels in lean males on a 13 week high fat diet compared to C57BL/J. This allele differs from Ildr2 by the presence of valine rather than alanine at amino acid residue 647 and the presence of alanine rather than threonine at amino acid residue 587. (J:138216)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Dbsm1 was identified in obese F2 male animals homozygous for Lep^ob.

References

• Original: J:138216 Dokmanovic-Chouinard M, et al., Positional cloning of 'Lisch-Like', a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet. 2008 Jul;4(7):e1000137
• All: 1 reference(s)