Paxip1^L5Jcs36
Chemically induced Allele Detail

Summary

• Symbol: Paxip1^L5Jcs36
• Name: PAX interacting (with transcription-activation domain) protein 1; lethal 5 John C Schimenti 36
• MGI ID: MGI:3814327
• Synonyms: L5Jcs36
• Gene: Paxip1 Location: Chr5:27945078-27996689 bp, - strand Genetic Position: Chr5, 13.23 cM, cytoband A3
• Alliance: Paxip1^L5Jcs36 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis caused a T-to-C transition resulting in a Leu857-to-Pro missense mutation in the C-terminal BRCT domain. Protein expression was markedly decreased by the mutation as determined by immunoblot analysis of embryonic fibroblasts. (J:140559)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Paxip1 Mutation: 47 strains or lines available

References

• Original: J:100332 Wilson L, et al., Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Genome Res. 2005 Aug;15(8):1095-105
• All: 3 reference(s)