Igh^tm1.1Hmj
Targeted Allele Detail

Summary

• Symbol: Igh^tm1.1Hmj
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Hans-Martin Jack
• MGI ID: MGI:3814340
• Synonyms: Igh^VDJ-
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140486
• Parent Cell Line: IDG3.2 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire J_Hwas replaced with a rearranged VDJ exon carrying a translational stop codon at amino acid position 3 of the leader peptide and a floxed neomycin resistance cassette. Mutant mice were crossed with Tg(EIIa-cre)C5379Lmgd mice resulting in excision of the selection cassette. (J:140486)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:140486 Lutz J, et al., VH replacement rescues progenitor B cells with two nonproductive VDJ alleles. J Immunol. 2006 Nov 15;177(10):7007-14
• All: 1 reference(s)