St6gal1^tm1Jlau
Targeted Allele Detail

Summary

• Symbol: St6gal1^tm1Jlau
• Name: beta galactoside alpha 2,6 sialyltransferase 1; targeted mutation 1, Joseph TY Lau
• MGI ID: MGI:3814350
• Synonyms: Siat1deltaP1, SiatdeltaP1
• Gene: St6gal1 Location: Chr16:23043490-23179100 bp, + strand Genetic Position: Chr16, 14.03 cM
• Alliance: St6gal1^tm1Jlau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140702
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 1.2-kb region that contained the transcriptional start site uniquely associated with the P1 promoter of this gene loci. This deletion region also contained exon H, an untranslated upstream exon that defines a liver specific mRNA isoform for this loci. Northern blot confirmed that no mRNA isoforms containing exon H were detected in the liver of homozygous mice, while levels of another mRNA isoform were present at normal levels. Total mRNA levels for this gene were depressed about 4-fold in the liver, slightly decreased in the spleen and were largely unchanged in the brain, liver, lung and kidney. (J:140702)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St6gal1 Mutation: 57 strains or lines available

References

• Original: J:140702 Appenheimer MM, et al., Biologic contribution of P1 promoter-mediated expression of ST6Gal I sialyltransferase. Glycobiology. 2003 Aug;13(8):591-600
• All: 9 reference(s)