Stxbp5^tm1Ytk
Targeted Allele Detail

Summary

• Symbol: Stxbp5^tm1Ytk
• Name: syntaxin binding protein 5 (tomosyn); targeted mutation 1, Yoshimi Takai
• MGI ID: MGI:3814545
• Gene: Stxbp5 Location: Chr10:9631291-9776823 bp, - strand Genetic Position: Chr10, 3.21 cM, cytoband A2
• Alliance: Stxbp5^tm1Ytk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140649
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding region and the 5' half of exon 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:140649)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stxbp5 Mutation: 66 strains or lines available

References

• Original: J:140649 Sakisaka T, et al., Dual inhibition of SNARE complex formation by tomosyn ensures controlled neurotransmitter release. J Cell Biol. 2008 Oct 20;183(2):323-37
• All: 5 reference(s)