Stau1^tm1Apa
Targeted Allele Detail

Summary

• Symbol: Stau1^tm1Apa
• Name: staufen double-stranded RNA binding protein 1; targeted mutation 1, Samuel Aparicio
• MGI ID: MGI:3814552
• Gene: Stau1 Location: Chr2:166789469-166838219 bp, - strand Genetic Position: Chr2, 87.22 cM
• Alliance: Stau1^tm1Apa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140557
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-beta-geo cassette was inserted into exon 5. This exon encodes the dsRNA-binding domain 3. Low level expression of a truncated protein product was confirmed by western blot analysis on forebrain extracts. (J:140557)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stau1 Mutation: 55 strains or lines available

References

• Original: J:140557 Vessey JP, et al., A loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16374-9
• All: 4 reference(s)