Kmt2a^tm1Saam
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1Saam
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Scott A Armstrong
• MGI ID: MGI:3814567
• Synonyms: Mll-AF4^stop
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1Saam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140628
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A cDNA encoding the C terminal portion of human AFF1 was inserted into exon 8, with an SV40 polyA signal and a PGK-puromycin gene. A loxP flanked stop cassette was inserted 5' to the Mll1-AF4 fusion exon. (J:140628)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Kmt2a^tm1Saam

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:140628 Krivtsov AV, et al., H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell. 2008 Nov 4;14(5):355-68
• All: 3 reference(s)