Pkdcc^tm1Hssk
Targeted Allele Detail

Summary

• Symbol: Pkdcc^tm1Hssk
• Name: protein kinase domain containing, cytoplasmic; targeted mutation 1, Hiroshi Sasaki
• MGI ID: MGI:3814573
• Gene: Pkdcc Location: Chr17:83522721-83532499 bp, + strand Genetic Position: Chr17, 52.25 cM
• Alliance: Pkdcc^tm1Hssk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140470
• Parent Cell Line: TT2F (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, which contains the transcription start site and the translation initiation sites for both transcripts, and part of intron 1 have been replaced by a neomycin resistance cassette. RT-PCR analysis of total mRNA from whole E9.5 mutant vs. wild type embryos confirmed the absence of transcripts in homozygous mutants. (J:140470)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pkdcc Mutation: 24 strains or lines available

References

• Original: J:140470 Imuta Y, et al., Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124). Dev Dyn. 2008 Dec 18;238(1):210-222
• All: 1 reference(s)