Tg(MT1A-Dyrk1a)#Xest
Transgene Detail

Summary

• Symbol: Tg(MT1A-Dyrk1a)#Xest
• Name: transgene insertion #, Xavier Estivill
• MGI ID: MGI:3814575
• Synonyms: TgDyrk1A
• Transgene: Tg(MT1A-Dyrk1a)#Xest Location: unknown
• Alliance: Tg(MT1A-Dyrk1a)#Xest page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MT1A-Dyrk1a)#Xest expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Dyrk1a (25255)

  Dyrk1a

  (MGI:1330299)

• Mutation details: The sheep promoter was used to drive expression of the full-length rat gene in the brain, heart and liver. Four lines were created (lines 9, 28, 31 and 33) that carry 2 to 20 copies of the transgene (2, 2, 20 and 5 copies, respectively). The pound symbol used when no line is specified and/or lines are pooled. (J:71821)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:71821 Altafaj X, et al., Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Hum Mol Genet. 2001 Sep 1;10(18):1915-23
• All: 11 reference(s)