Trpm7^tm1Clph
Targeted Allele Detail

Summary

• Symbol: Trpm7^tm1Clph
• Name: transient receptor potential cation channel, subfamily M, member 7; targeted mutation 1, David E Clapham
• MGI ID: MGI:3814705
• Synonyms: Trpm7^fl
• Gene: Trpm7 Location: Chr2:126633485-126718150 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband F2
• Alliance: Trpm7^tm1Clph page

Representative images of grossly deformed, nonviable Trpm7^tm1Clph/Trpm7^tm1Clph Tg(CAG-cre/Esr1*)5Amc/0 embryos at E9.5 and E10.5

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140630
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around exon 17 and an frt-flanked neo cassette was inserted within the floxed locus. The neo cassette was removed by in vivo flp mediated recombination. (J:140630)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpm7 Mutation: 102 strains or lines available

References

• Original: J:140630 Jin J, et al., Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31;322(5902):756-60
• All: 20 reference(s)