Trpm7^tm1.1Clph
Targeted Allele Detail

Summary

• Symbol: Trpm7^tm1.1Clph
• Name: transient receptor potential cation channel, subfamily M, member 7; targeted mutation 1.1, David E Clapham
• MGI ID: MGI:3814706
• Gene: Trpm7 Location: Chr2:126633485-126718150 bp, - strand Genetic Position: Chr2, 61.76 cM, cytoband F2
• Alliance: Trpm7^tm1.1Clph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140630
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination of Trpm7^tm1Clph resulted in deletion of exon 17. Deletion of exon 17 removes the sequence preceding the first transmembrane domain and generates a frame shift mutation. (J:140630)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm7 Mutation: 102 strains or lines available

References

• Original: J:140630 Jin J, et al., Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. 2008 Oct 31;322(5902):756-60
• All: 2 reference(s)