Gt(ROSA)26Sor^{tm2.1(Cd74/MOG)Awai}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2.1(Cd74/MOG)Awai}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Ari Waisman
• MGI ID: MGI:3814860
• Synonyms: IiMOG
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2.1(Cd74/MOG)Awai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140751
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Cre-mediated recombination removed the STOP cassette and allow for expression of the Cd74-MOG fusion. (J:140751)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:140751 Frommer F, et al., Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion. J Immunol. 2008 Oct 15;181(8):5748-59
• All: 3 reference(s)