Hoxa11^tm1Dmwe
Targeted Allele Detail

Summary

• Symbol: Hoxa11^tm1Dmwe
• Name: homeobox A11; targeted mutation 1, Deneen M Wellik
• MGI ID: MGI:3814861
• Synonyms: Hoxa11eGFP
• Gene: Hoxa11 Location: Chr6:52219086-52222784 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa11^tm1Dmwe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140709
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An eGFP construct was inserted 18 bp downstream of the start site in exon 1 replacing most of exon 1. This was followed by an SV40 T-antigen stop sequence and a self-excising neo cassette in reverse orientation. Cre mediated excision of the neo cassette occurs in the testes. (J:140709)

Expression

In Mice Carrying this Mutation:	243 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxa11 Mutation: 11 strains or lines available

References

• Original: J:140709 Nelson LT, et al., Generation and expression of a Hoxa11eGFP targeted allele in mice. Dev Dyn. 2008 Nov;237(11):3410-6
• All: 7 reference(s)