Tg(TcraAV19AJ33)1Shima
Transgene Detail

Summary

• Symbol: Tg(TcraAV19AJ33)1Shima
• Name: transgene insertion 1, Michio Shimamura
• MGI ID: MGI:3814864
• Synonyms: Valpha19⁺, Valpha19i, Valpha19iTg, Valpha19 Tg⁺
• Transgene: Tg(TcraAV19AJ33)1Shima Location: unknown
• Alliance: Tg(TcraAV19AJ33)1Shima page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraAV19AJ33)1Shima expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)

• Mutation details: A recombined Tcra gene associated with Valpha19 NK T cells was used in a transgene construct. The Valpha19-Jalpha26 (AV19-AJ33) transgene with the endogenous TCR alpha promoter and enhancer were injected into TCR Ca-deficient fertilized eggs. T cells expressing the transgenic TCR-alpha chain were detected in the liver. (J:140924)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:140924 Okamoto N, et al., Synthetic alpha-mannosyl ceramide as a potent stimulant for an NKT cell repertoire bearing the invariant Valpha19-Jalpha26 TCR alpha chain. Chem Biol. 2005 Jun;12(6):677-83
• All: 4 reference(s)