Six3^tm3.1Gco
Targeted Allele Detail

Summary

• Symbol: Six3^tm3.1Gco
• Name: sine oculis-related homeobox 3; targeted mutation 3.1, Guillermo Oliver
• MGI ID: MGI:3814870
• Synonyms: Six3^ki
• Gene: Six3 Location: Chr17:85921036-85933619 bp, + strand Genetic Position: Chr17, 55.42 cM
• Alliance: Six3^tm3.1Gco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140315
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: This allele was produced from Six3^tm3Gco by germline expression of Foxg1^tm1(cre)Skm which results in excision of the 5' stop codon and its associated selection cassette. (J:140315)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six3 Mutation: 13 strains or lines available

References

• Original: J:140315 Geng X, et al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
• All: 1 reference(s)