Six3^{tm4(cre/ERT2)Gco}
Targeted Allele Detail

Summary

• Symbol: Six3^{tm4(cre/ERT2)Gco}
• Name: sine oculis-related homeobox 3; targeted mutation 4, Guillermo Oliver
• MGI ID: MGI:3814875
• Synonyms: Six3^{tm4(cre/Esr1)Gco}
• Gene: Six3 Location: Chr17:85921036-85933619 bp, + strand Genetic Position: Chr17, 55.42 cM
• Alliance: Six3^{tm4(cre/ERT2)Gco} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140315
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Six3^{tm4(cre/ERT2)Gco} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Six3 (MGI:102764)

• Mutation details: A creER^T2 cassette was inserted in frame 22 nucleotides down stream from the start codon. A floxed selection cassette was also inserted but further downstream but still in exon 1. (J:140315)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Six3 (mouse) Summary of all recombinase alleles driven by Six3. Alliance mouse Six3 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six3 Mutation: 13 strains or lines available

References

• Original: J:140315 Geng X, et al., Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell. 2008 Aug;15(2):236-47
• All: 5 reference(s)