Cth^tm1Liwu
Targeted Allele Detail

Summary

• Symbol: Cth^tm1Liwu
• Name: cystathionine gamma lyase; targeted mutation Lingyun Wu
• MGI ID: MGI:3814989
• Synonyms: Cgl^-, CSE^-
• Gene: Cth Location: Chr3:157599885-157630714 bp, - strand Genetic Position: Chr3, 81.55 cM
• Alliance: Cth^tm1Liwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140705
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1, 2 and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and kidney extracts. (J:140705)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cth Mutation: 33 strains or lines available

References

• Original: J:140705 Yang G, et al., H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008 Oct 24;322(5901):587-90
• All: 51 reference(s)