Cxadr^tm1Know
Targeted Allele Detail

Summary

• Symbol: Cxadr^tm1Know
• Name: coxsackie virus and adenovirus receptor; targeted mutation 1, Kirk U Knowlton
• MGI ID: MGI:3815066
• Synonyms: Cxadr^flox
• Gene: Cxadr Location: Chr16:78098377-78156662 bp, + strand Genetic Position: Chr16, 45.28 cM, cytoband C
• Alliance: Cxadr^tm1Know page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140870
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2, which contains the ATG start codon, was floxed by the following construct. A loxP site was inserted upstream of exon 2, and a loxP site and a Frt-flanked neomycin cassette was inserted downstream of exon 2. Correct targeting was confirmed by genomic PCR. (J:140870)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxadr Mutation: 15 strains or lines available

References

• Original: J:140870 Lim BK, et al., Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug;118(8):2758-70
• All: 2 reference(s)