Cxadr^tm2Know
Targeted Allele Detail

Summary

• Symbol: Cxadr^tm2Know
• Name: coxsackie virus and adenovirus receptor; targeted mutation 2, Kirk U Knowlton
• MGI ID: MGI:3815069
• Synonyms: Car
• Gene: Cxadr Location: Chr16:78098377-78156662 bp, + strand Genetic Position: Chr16, 45.28 cM, cytoband C
• Alliance: Cxadr^tm2Know page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140870
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2, which contains the ATG start codon, was disrupted by the insertion of a beta-Gal/Neo cassette. Gene inactivation was confirmed by immunoblot analysis of embryonic tissue. (J:140870)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxadr Mutation: 15 strains or lines available

References

• Original: J:140870 Lim BK, et al., Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008 Aug;118(8):2758-70
• All: 1 reference(s)