Slc32a1^tm1Lowl
Targeted Allele Detail

Summary

• Symbol: Slc32a1^tm1Lowl
• Name: solute carrier family 32 (GABA vesicular transporter), member 1; targeted mutation 1, Bradford B Lowell
• MGI ID: MGI:3815083
• Synonyms: Vgat^flox, Viaat-lx-lx
• Gene: Slc32a1 Location: Chr2:158452687-158457668 bp, + strand Genetic Position: Chr2, 78.72 cM, cytoband H1-3
• Alliance: Slc32a1^tm1Lowl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140858
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon 2 and an frt flanked kan/neo cassette was inserted via homologous recombination. The kan/neo cassette was subsequently removed via in vivo Flp mediated recombination. (J:140858)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc32a1 Mutation: 55 strains or lines available

References

• Original: J:140858 Tong Q, et al., Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008 Sep;11(9):998-1000
• All: 83 reference(s)