Nr1i3^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Nr1i3^tm1.1Arte
• Name: nuclear receptor subfamily 1, group I, member 3; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:3815105
• Gene: Nr1i3 Location: Chr1:171041503-171046414 bp, + strand Genetic Position: Chr1, 79.21 cM
• Alliance: Nr1i3^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140975
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Nearly all of the human sequence in Nr1i3^{tm1(NR1I3)Arte} was deleted by germ line, phiC31 mediated recombination leaving only mouse exon 1 and human exon 2. ES cells originally used contained Nr1i2^{tm1(NR1I2)Arte}. (J:140975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Nr1i3 Mutation: 36 strains or lines available

References

• Original: J:140975 Scheer N, et al., A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J Clin Invest. 2008 Sep;118(9):3228-39
• All: 8 reference(s)