Sptlc2tm1Jia
Targeted Allele Detail
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Symbol: |
Sptlc2tm1Jia |
Name: |
serine palmitoyltransferase, long chain base subunit 2; targeted mutation 1, Xian-cheng Jiang |
MGI ID: |
MGI:3815117 |
Synonyms: |
LCB2 |
Gene: |
Sptlc2 Location: Chr12:87351832-87435129 bp, - strand Genetic Position: Chr12, 41.52 cM, cytoband E
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Alliance: |
Sptlc2tm1Jia page
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Germline Transmission: |
Earliest citation of germline transmission:
J:140627
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 1, which contains the ATG start codon, was replaced with a neomycin resistance cassette. Southern blotting confirmed correct targeting of ES cells. Immunoblot analysis on heterozygote liver extracts indicated protein expression was reduced by more than half, confirming gene inactivation.
(J:140627)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sptlc2 Mutation: |
171 strains or lines available
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Original: |
J:140627 Hojjati MR, et al., Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice. Biochim Biophys Acta. 2005 Oct 15;1737(1):44-51 |
All: |
7 reference(s) |
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