Sorl1^tm1Bujo
Targeted Allele Detail

Summary

• Symbol: Sorl1^tm1Bujo
• Name: sortilin-related receptor, LDLR class A repeats-containing; targeted mutation 1, Hideaki Bujo
• MGI ID: MGI:3815203
• Synonyms: Lr11^-
• Gene: Sorl1 Location: Chr9:41876016-42035593 bp, - strand Genetic Position: Chr9, 23.55 cM, cytoband B
• Alliance: Sorl1^tm1Bujo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140878
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brain and kidney extracts. (J:140878)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sorl1 Mutation: 132 strains or lines available

References

• Original: J:140878 Jiang M, et al., Ang II-stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice. J Clin Invest. 2008 Aug;118(8):2733-46
• All: 4 reference(s)