Prm3^tm1Grz
Targeted Allele Detail

Summary

• Symbol: Prm3^tm1Grz
• Name: protamine 3; targeted mutation 1, Pawel Grzmil
• MGI ID: MGI:3815297
• Gene: Prm3 Location: Chr16:10608372-10608778 bp, - strand Genetic Position: Chr16, 5.84 cM
• Alliance: Prm3^tm1Grz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the entire coding sequence of the locus. Gene inactivation was confirmed by a lack of detectable protein in immunoblot assays of homozygote testis extract. Expression of the nearby genes Prm1 and Tnps2 were unaffected as determined by Northern Blot. (J:140818)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prm3 Mutation: 8 strains or lines available

References

• Original: J:140818 Grzmil P, et al., Prm3, the fourth gene in the mouse protamine gene cluster, encodes a conserved acidic protein that affects sperm motility. Biol Reprod. 2008 Jun;78(6):958-67
• All: 1 reference(s)