Sct^tm1Inis
Targeted Allele Detail

Summary

• Symbol: Sct^tm1Inis
• Name: secretin; targeted mutation 1, Ichiko Nishijima
• MGI ID: MGI:3815315
• Gene: Sct Location: Chr7:140858243-140859046 bp, - strand Genetic Position: Chr7, 86.59 cM, cytoband F5
• Alliance: Sct^tm1Inis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140787
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was replaced with a lacZ reporter and PGK-neo cassette. RT-PCR analysis confirmed the absence of expression mRNA in homozygotes. LacZ expression was detected in the hippocampus, posterior commissure, habenula, cerebellum, olfactory glomeruli, and dorsal tegmental nucleus. (J:140787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sct Mutation: 11 strains or lines available

References

• Original: J:140787 Yamagata T, et al., Impaired hippocampal synaptic function in secretin deficient mice. Neuroscience. 2008 Jul 17;154(4):1417-22
• All: 4 reference(s)