Gt(ROSA)26Sor^tm1(Crh)Jde
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(Crh)Jde
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jan Deussing
• MGI ID: MGI:3815322
• Synonyms: CRH-COE, R26^flopCrh, Rosa26^{+/flopCrh-IRES-LacZ}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(Crh)Jde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:149207
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(Crh)Jde expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Crh (MGI:88496)

• Mutation details: Coding sequence for murine Crh gene and an IRES-lacZ sequence was preceded by a loxP-flanked transcriptional terminator and then was knocked into the Gt(ROSA)26Sor locus. Upon cre recombinase expression and excision of the loxP-stop sequence, the Crh and lacZ reporter gene are predicted to be expressed. (J:149207)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:149207 Lu A, et al., Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol Psychiatry. 2008 Nov;13(11):1028-42
• All: 10 reference(s)